Tentative Schedule

25th American Peptide Symposium – June 17-22, 2017 – Whistler BC

Saturday, June 17, 2017

01:00 pm - 06:00 pm Registration Grand Foyer
02:00 pm - 05:30 pm APS Council Meeting To Be Announced
04:00 pm - 05:30 pm L01, KN Workshop:
How to Break Bottlenecks in Your Peptide Synthesis Workflow.
Elizabeth Denton, PhD
Fitzsimmons
06:00 pm - 07:00 pm L01, KN Opening Remarks and Opening Plenary Keynote:
De Novo Peptide Design
Dr. David Baker, University of Washington
Session Chairs:
John Vederas, University of Alberta
Jonathan Lai, Albert Einstein College of Medicine
Introduces David Baker
Sea to Sky Ballroom A
07:00 pm - 10:00 pm Opening Reception Grand Foyer

Sunday, June 18, 2017

07:30 am - 04:30 pm Registration Grand Foyer
08:00 am - 08:15 am Opening Remarks:
John Vederas, University of Alberta
Jonathan Lai, Albert Einstein College of Medicine
Sea to Sky Ballroom A
08:15 am - 10:05 am SESSION 1
Peptides and Enzymes
Session Chairs:
Dewey McCafferty, Duke University,
Fa Liu, Novo Nordisk
Sea to Sky Ballroom A
08:15 am - 08:40 am L02 - Peptide Probes of Epigenetic Demethylation Complex Protein-Protein Interactions
Dewey McCafferty
Duke University
08:40 am - 09:00 am L03 - Modulation of the Primary and Secondary Structure of Apelin to Optimize Stability, Bias Signalling and Modulate Pathophysiological Response
Éric Marsault
, Université de Sherbrooke/td>
09:00 am - 09:25 am L04 - Understanding and Engineering Bifunctional Enzymes for Nonribosomal Peptide Synthesis
Sylvie Garneau-Tsodikova
University of Kentucky
09:25 am - 09:45 am L05 - Clarifying the Complexity of Chromatin with Peptide Chemistry
Champak Chatterjee
University of Washington
09:45 am - 10:05 am L06 - Peptide Ligases: Site-specific Molecular Staplers
James Tam
Nanyang Technological University
10:05 am - 10:30 am Coffee with Exhibitors & Posters Grand Foyer
Sea to Sky Ballroom B & C
10:30 am - 12:20 pm SESSION 2
Membrane Active Peptides
Session Chairs:
Natia Tsomaia, IPSEN
Charles Deber, University of Toronto
Sea to Sky Ballroom A
10:30 am - 10:55 am L07 - Membrane Interactions and Cell Penetrating Properties of Cyclotides
David Craik
The University of Queensland
10:55 am - 11:20 am L08 - Solid-State NMR Spectroscopy Reveals the Allosteric Regulation of the Sarcoplasmic Reticulum
Ca2+-ATPase by Phospholamban
Gianluigi Veglia
University of Minnesota
11:20 am - 11:35 am L09, YI - Structure-Guided Development of a Peptide Antagonist for EphA4, A Cell-Surface Receptor Linked to Neurodegeneration
Erika J. Olson
The Scripps Research Institute
11:35 am - 12:00 pm L10 - Peptides as Alternatives to Antibiotics
Bob Hancock
University of British Columbia
12:00 pm - 12:20 pm L11 - A New, Quantitative Assay for Cytosolic Penetration of Peptides and other Molecules
Joshua Kritzer
Tufts University
12:20 pm - 01:45 pm Lunch - provided Grand Foyer
Sea to Sky Ballroom B & C
12:15 pm - 01:45 pm International Liaison Meeting TBD
01:50 pm - 03:30 pm SESSION 3
Peptide Synthesis, Structure, Function
Session Chairs:
David Craik, The University of Queensland
Michael Kay, University of Utah
Sea to Sky Ballroom A
01:50 - 02:15 pm L12 - Protein-peptide Interactions that Control Apoptosis
Amy Keating
Massachusetts Institute of Technology
02:15 pm - 02:40 pm L13 - Application of N-Sulfanylethylanilide (SEAlide) Unit to Protein Chemical Synthesis and Protein Enrichment
Akira Otaka
Tokushima University
02:40 pm - 03:05 pm L14 - Rational Redesign of the Collagen Triple Helix Interface
David Chenowith
University of Pennsylvania
03:05 pm - 03:30 pm L15 - Linear and Cyclic Azapeptide Strategies for Conceiving Cluster of Differentiation-36 Scavenger Receptor Modulators
William Lubell
Université de Montréal
03:30 pm - 03:50 pm L16 - Bulky Dehydroamino Acids Impart Proteolytic Stability to Peptides
Steven Castle
Brigham Young University
04:00 pm - 05:30 pm Merrifield Award Lectures
Sea to Sky Ballroom A
04:00 pm - 04:05 pm Introduction:
Philip Dawson, The Scripps Research Institute
04:05 pm - 04:45 pm L17, AW - The Use of Synthetic Peptides to Probe Complex Interactions in Proteins and the Development of Synthetic Peptide Drugs and Vaccines
Robert Hodges
University of Colorado School of Medicine
04:45 pm - 04:50 pm Introduction:
Philip Dawson, The Scripps Research Institute
04:50 pm - 05:30 pm L18, AW - Peptides in Membranes: From Structure to Drug Design
Charles Deber
University of Toronto
07:00 pm - 09:00 pm Student Mixer Garibaldi

Monday, June 19, 2017

07:30 am - 04:30 pm Registration Grand Foyer
08:00 pm - 10:10 am SESSION 4
Post-Translational and Chemical Modifications
Session Chairs:
Michael Burkart, University of California, San Diego
Justin Holub, Ohio University
Sea to Sky Ballroom A
08:00 am - 08:25 am L19 - Engineering Protein Interactions in Type II Non-Ribosomal Peptide Synthetases
Michael Burkart
University of California, San Diego
08:25 am - 08:50 am L20 - Cross-Talk Between Chromatin Recognition and Modification in Histone Demethylases
Danica Fujimori
, University of California, San Francisco
08:50 am - 09:05 am L21, YI - Affecting Activity of the Linear Ubiquitin Chain Assembly Complex, LUBAC, with Stapled Alpha-Helical Peptides
Amanda Whiting
National Cancer Institute
09:05 am - 09:30 am L22 - Genetically-Encoded Chemically-Modified Peptides
Ratmir Derda
University of Alberta
09:30 am - 09:50 am L23 - Affinity Labeling of Histone Peptides Containing Trimethyllysine
Marcey Waters
University of North Carolina, Chapel Hill
09:50 am - 10:10 am L24 - New Coumarin- and Nitrodibenzofuran-Based Photoremovable Protecting Groups for Cysteine Protection in Solid Phase Peptide Synthesis
Mark DiStefano
University of Minnesota
10:10 am - 10:30 am Coffee with Exhibitors & Posters Grand Foyer
Sea to Sky Ballroom B & C
10:30 am - 12:10 pm SESSION 5
Computational Design and Recognition
Session Chairs:
David Baker, University of Washington,
Jung-Mo Ahn, University of Texas at Dallas
Sea to Sky Ballroom A
10:30 am - 10:55 am L25 - Using Theory and Computation to Design Polypeptide Materials
Jeffery Saven
University of Pennsylvania
10:55 am - 11:20 am L26 - Tertiary Alphabet for the Observable Structural Universe
Gevorg Grigoryan
Dartmouth College
11:20 am - 11:45 am L27 - Accurate Structural Modeling and High-Affinity Design of Peptide-Protein Interactions using Rosetta FlexPepDock
Ora Schueler-Furman
Hebrew University of Jerusalem
11:45 am - 12:00 pm L28, YI - Development of a Peptide Macrocycle FXII Inhibitor for Safe Anticoagulation Therapy
Jonas Wilbs
Ecole Polytechnique Fédérale de Lausanne
12:00 pm - 12:20 pm L29 - Minimalist Protein ME47 Targets the Myc/Max:E-box DNA Network and Decreases Tumor Xenograft Growth
Jumi Shin
University of Toronto
12:20 pm - 01:45 pm Lunch - provided Grand Foyer
Sea to Sky Ballroom B & C
01:50 pm - 03:30 pm SESSION 6
Peptidomimetics and Non-Natural Backbones
Session Chairs:
Sam Gellman, University of Wisconsin at Madison
Kit Lam, University of California at Davis
Sea to Sky Ballroom A
01:50 pm - 02:15 pm L30 - Impact of Backbone Modifications on Informational Properties of Peptides
Sam Gellman
University of Wisconsin-Madison
02:15 pm - 02:40 pm L31 - Interfacing Oligourea Foldamers with Alpha-Peptides: An Approach to Alpha-Helix Mimicry and to the Creation of Composite Protein-Like Architectures
Gilles Guichard
University of Bordeaux and CNRS
02:40 pm - 03:05 pm L32 - Peptide N-Amination: A Versatile Backbone Modification for Constrained Proteomimetics
Juan Del Valle
University of South Florida
03:05 pm - 03:25 pm L33 - Targeting Protein-Protein Interactions with Peptide-based Inhibitors
Kristian Strømgaard
University of Copenhagen
03:40 pm - 04:05 pm L34, AW - Goodman Lecture
From Venoms to Drugs
Paul Alewood
The University of Queensland
Introduction:
Ved Srivastava, Intarcia Therapeutics
04:05 pm - 05:35 pm SESSION 7
Peptide Therapeutics and Diagnostics I
Session Chairs:
Les Miranda, Amgen
Waleed Danho
Sea to Sky Ballroom A
04:05 pm - 04:30 pm L35 - From Twice-daily Injection to Once or Twice a Yearly Dosing of GLP-1 Agonist for Potential Treatment for Type 2 Diabetes
Ved Srivastava
Intarcia Therapeutics
04:30 pm - 04:55 pm L36 - Development of a Potent D-Protein Inhibitor of VEGF-A with Reduced Immunogenicity and a Longer Half-Life
Dana Ault-Riche
Reflexion Pharmaceuticals
04:55 pm - 05:15 pm L37 - Conformational, Topographical, Receptor and Dynamic Consideration in the Design of Biostable, Receptor Selective Ligands for the Melanocortin Receptors
Victor Hruby
University of Arizona
05:15 pm - 05:35 pm L38 - Breast Cancer Targeting Peptides and Peptide-Drug Conjugates for Increased Therapeutic Efficacy of Current Chemotherapeutic Drugs against Triple Negative Breast Cancer
Kamaljit Kaur
Chapman University
05:35 pm - 08:00 pm Group 1 Poster Session
Reception
Grand Foyer
Sea to Sky Ballroom B & C

Tuesday, June 20, 2017

07:30 am - 12:30 pm Registration Grand Foyer
08:00 am - 08:35 am L39, AW - du Vigneaud Lecture I
Chemical Forces that Stabilize Proteins
Ronald Raines
University of Wisconsin
Introduction:
Robin Offord, Mintaka Foundation
Sea to Sky Ballroom A
08:35 am - 10:05 am SESSION 8
Glycopeptides
Session Chairs:
James Paulson, The Scripps Research Institute
Fernando Albericio, University of KwaZulu-Natal
Sea to Sky Ballroom A
08:35 am - 09:00 am L40 - HIV Glycosylation
James Paulson
The Scripps Research University
09:00 am - 09:25 am L41 - Microbial Natural Products Discovery and Diversification
Jon Thorson
University of Kentucky
09:25 am - 09:50 am L42 - Elucidating the Features of Effective Vaccines
Laura Kiessling
University of Wisconsin
09:50 am - 10:05 am L43, YI - Engineering Dengue EDIII Immunogens to Elicit Broadly Neutralizing Antibody Responses
Julia C. Frei
Albert Einstein College of Medicine
10:05 am - 10:30 am Coffee with Exhibitors & Posters Grand Foyer
Sea to Sky Ballroom B & C
10:30 am - 11:00 am L44, AW - Makineni Lecture
Novel Peptide-like Inhibitors of the Proteasome Ubiquitin Receptor Rpn13 Proteasome Inhibitors and Their Mechanism of Action: A Promising New Approach to Chemotherapy
Thomas Kodadek
The Scripps Research University
Introduction:
Marcey Waters, University of North Carolina, Chapel Hill
Sea to Sky Ballroom A
11:00 am - 12:45 am SESSION 9
Synthetic Methods
Session Chairs:
Stephen Kent, University of Chicago,
Andrei Yudin, University of Toronto
Sea to Sky Ballroom A
11:00 am - 11:25 am L45 - Automated Flow Peptide Synthesis: Toward Amide Bonds at Nature’s Pace
Bradley Pentelute
Massachusetts Institute of Technology
11:25 am - 11:50 am L46 - Organotrifluoroborates as Radioprosthetics that Enable Facile, User-friendly 18F-Labeling for Turning Peptides into Pet Imaging Agents
David Perrin
University of British Columbia
11:50 am - 12:10 pm L47 - Peptide Therapeutics Method Development: Increasing Efficiency and Purity of SPPS using Parallel Synthesis Optimization with Induction Heating
James Cain
Gyros Protein Technologies
12:10 pm - 12:30 pm L48 - Cyclic Urethane Chemistry for Synthesis and Sequencing of Cyclic Peptides
Monika Raj
Seton Hall University
12:30 pm - 12:50 pm L49 - A New Level of Efficiency for SPPS
Jonathan Collins
CEM Corporation
12:50 pm - 02:50 pm Dr. Bert L. Schram Young Scientists’ Lunch & Mixer
Graduate students & post-docs only
Garibaldi
12:50 pm - 02:00 pm Peptide Science Editorial Board Lunch & Meeting
Editors and Editorial Advisory Board
TBA
03:00 pm - 05:00 pm Workshop on Career Development: Job Search Strategy and Preparation.
Organized by Natia Tsomaia, IPSEN
Ellie Eckhoff
Senior Vice President, ClearRock, Inc.
Sponsored by Scilligence
Fitzsimmons

Wednesday, June 21, 2017

07:30 am - 04:00 pm Registration Grand Foyer
08:00 am - 08:35 am L50, AW - du Vigneaud Lecture II
Combinatorial Lanthipeptide Biosynthesis
Wilfred van der Donk
Howard Hughes Medical Institute and University of Illinois at Urbana-Champaign
Introduction:
John Vederas, University of Alberta
Sea to Sky Ballroom A
08:35 am - 10:10 am SESSION 10
Peptide Therapeutics and Diagnostics II
Session Chairs:
Thomas Kodadek, The Scripps Research Institute
Wendy Hartsock, Ferring Research Institute, Inc.
Sea to Sky Ballroom A
08:35 am - 09:00 am L51 - Discovery of Macrocyclic Peptidomimetics Targeting Protein-Protein Interactions
Hyun-Suk Lim
Pohang University of Science and Technology
09:00 am - 09:25 am L52 - Discovery of Soluble, Biophysically Stable Glucagon Analogs with Minimal Change to Native Sequence
John Mayer
Novo Nordisk Research Center
09:25 am - 09:50 am L53 - Systematic Discovery and Development of Peptidic Molecular Guidance Systems for the Diagnosis and Treatment of Cancer
Kathlynn Brown
SRI International
09:50 am - 10:10 am L54 - Sensitivity of the Opioid Activity Profile of CJ-15,208 Analogs to Ring Substitution
Jane Aldrich
University of Florida
10:10 am - 10:35 am Coffee with Exhibitors & Posters Grand Foyer
Sea to Sky Ballroom B & C
10:35 am - 12:05 pm SESSION 11
Peptide Libraries
Session Chairs:
Hiroaki Suga, The University of Tokyo
Richard Houghten, Torrey Pines Institute
Sea to Sky Ballroom A
10:35 am - 11:00 am L55 - The RaPID Discovery of Pseudo-Natural Peptides
Hiroaki Suga
The University of Tokyo
11:00 am - 11:25 am L56 - From Natural Antibodies to Synthetic Proteins
Sachdev Sidhu
University of Toronto
11:25 am - 11:40 am L57, YI - Peptide Macrocyclization Inspired by Non-Ribosomal Imines
Lara Malins
The Scripps Research Institute
11:40 am - 12:05 pm L58 - An Engineered Tumor Targeting Knottin Peptide is a Versatile Agent for Imaging, Drug Delivery, and Immunotherapy
Jennifer Cochran
Stanford University
12:10 pm - 12:20 pm Announcement of 26th APS Sea to Sky Ballroom A
12:20 pm - 01:45 pm Lunch - provided TBA
12:20 pm - 01:45 pm Vincent du Vigneaud Award Lunch
Sponsored by BACHEM
By Invitation
Garibaldi
03:40 pm - 05:35 pm SESSION 12
Constrained Peptides and Macrocycles
Session Chairs:
Paramjit Arora, New York University
Federico Bernal, National Cancer Institute
Sea to Sky Ballroom A
03:40 pm - 04:05 pm L59 - Minimal Coiled Coils and their Potential as Protein-Protein Interaction Inhibitors
Paramjit Arora
New York University
04:05 pm - 04:30 pm L60 - Targeting Kinase Regulation with Constrained Peptides
Eileen Kennedy
University of Georgia, College of Pharmacy
04:30 pm - 04:45 pm L61, YI - Oxadiazole Grafts in Peptide Macrocycles
Solomon Appavoo
University of Toronto
04:45 pm - 05:10 pm L62 - How Do Cell-Penetrating Peptides Work?
Dehua Pei
The Ohio State University
05:10 pm - 05:35 pm L63 - Exploring Macrocyclic Peptide Cell Permeability: Stapled p53 Peptide Model System
Tomi Sawyer
Merck & Company, Inc.
05:35 pm - 08:00 pm Group 2 Poster Session
Reception
Grand Foyer
Sea to Sky Ballroom B & C

Thursday, June 22, 2017

07:30 am - 10:30 am Registration Grand Foyer
08:15 am - 10:10 am SESSION 13
Natural Product Biosynthesis
Session Chairs:
Wilfred van der Donk, University of Illinois
Yuki Goto, The University of Tokyo
Sea to Sky Ballroom A
08:15 am - 08:40 am L64 - In Vitro Reconstitution and Mechanistic Insights into Thiopeptide Biosynthesis
Douglas Mitchell
University of Illinois at Urbana-Champaign
08:40 am - 09:05 am L65 - Biosynthesis of RiPPs on the Coral Reef
Eric Schmidt
University of Utah
09:05 am - 09:20 am L66, YI - Enzymatic Macrocyclization of Non-Natural and Hybrid Polyketide Peptides”
Emilia Oueis
University of St Andrews
09:20 am - 09:45 am L67 - Making and Breaking Lasso Peptides
A. James Link
Princeton University
09:45 am - 10:10 am L68 - Chemoenzymatic Platforms for the Discovery of New Peptide Therapeutics
Albert Bowers
University of North Carolina, Eshelman School of Pharmacy
10:10 am - 10:35 am Coffee Break Grand Foyer
10:35 am - 12:10 pm SESSION 14
Peptide Materials and Nanomedicine
Session Chairs:
Neal Zondlo, University of Delaware
Bradley Nilsson, University of Rochester
Sea to Sky Ballroom A
10:35 am - 11:00 am L69 - The Design Evolution of Anticancer Peptides from Self-Assembled Hydrogels and How Cancer Cells Gain Resistance to their Action
Joel Schneider
National Cancer Institute
11:00 am - 11:25 am L70 - Intracellular Delivery of Therapeutic Peptide Using Enzymatically Cleavable Peptide Amphiphiles
James LaBelle
University of Chicago
11:25 am - 11:50 am L71 - Protein Misfolding and Chemical Evolution
David Lynn
Emory University
11:50 am - 12:05 pm L72, YI - Palladium in Chemical Protein Synthesis and Manipulation
Muhammad Jbara
Technion-Israel Institute of Technology Haifa
12:05 pm - 12:25 pm L73 - Peptide-CRM197 Conjugate Vaccines - Considerations for Process Development
Anouk Dirksen
Pfizer Inc.
12:25 pm - 01:40 pm Lunch Break - on your own  
01:40 pm 03:15 pm SESSION 15
Peptide Assemblies and Complexes
Session Chairs:
James Nowick, University of California, Irvine
Ivan Korendovych ,Syracuse University
Sea to Sky Ballroom A
01:40 pm - 02:05 pm L74 - Unlocking the Mysteries of Amyloid Diseases with Macrocyclic Beta-Sheet Peptides
James Nowick
University of California, Irvine
02:05 pm - 02:30 pm L75 - Aromatic Foldamer-Based Protein Mimicry and Recognition
Ivan Huc
University of Bordeaux and CNRS
02:30 pm - 02:55 pm L76 - Thioamide Probes for Studying Peptide Stability In Vitro and In Vivo
E. James Petersson
University of Pennsylvania
02:55 pm - 03:15 pm L77 - Protein Evolution Yields Cyclic Peptide Inhibitors of HIV-1 Propagation
Brian McNaughton
Colorado State University
03:15 pm - 04:05 pm Closing Remarks & Thanks
John Vederas & Jonathan Lai
L78 - Inventing Synthetic Peptide & Protein Chemistries to Reveal how Enzymes Work
Stephen Kent
University of Chicago
Introduction:
Philip Dawson, The Scripps Research Institute
06:30 pm - 10:00 pm Closing Banquet Sea to Sky Ballroom A

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